Effect of retinoic acid and interferon alpha on granulocyte-macrophage colony forming cells in chronic myeloid leukemia: Increased inhibition by all- trans - and 13- cis -retinoic acids in advanced stage disease
Identifieur interne : 000951 ( Main/Exploration ); précédent : 000950; suivant : 000952Effect of retinoic acid and interferon alpha on granulocyte-macrophage colony forming cells in chronic myeloid leukemia: Increased inhibition by all- trans - and 13- cis -retinoic acids in advanced stage disease
Auteurs : Grace E. Sagayadan [États-Unis] ; Peter H. Wiernik [États-Unis] ; Nancy Sun [États-Unis] ; Greg Ahearn [États-Unis] ; Deborah Thompson [États-Unis] ; Steven J. Hallam [États-Unis] ; Xiao-Ping Hu [États-Unis] ; Janice P. Dutcher [États-Unis] ; Robert E. Gallagher [États-Unis]Source :
- Leukemia Research [ 0145-2126 ] ; 1994.
English descriptors
- Teeft :
- Acute promyelocytic leukemia, Albert einstein cancer center, Annealing temperature, Antisense primer, Assay, Blast cells, Blastic, Blastic crisis, Bone marrow, Cfc, Chain reaction, Chronic myeloid leukemia, Chronic phase, Clonal growth, Clonogenic, Clonogenic assays, Cmlcp cases, Colony formation, Colony morphology, Colony size, Current study, Differentiation therapy, Fetal calf serum, Individual points, Inftr, Inhibition, Inhibition curves, Interferon, Leukemia, Mrna, Myelogenous leukemia, Myeloid, Myeloproliferative disease, None none, Peripheral blood, Primer, Primer pair, Promyelocytic, Propositus case, Recombinant, Recombinant interferon, Retinoic, Retinoic acid, Retinoic acids, Sense primer, Single agent, Strong inhibition, Titration curves, Total clones, Various concentrations.
Abstract
Abstract: Granulocyte-macrophage colony forming units (CFU-GM) from patients with advanced stage chronic myelogenous leukemia (CML), i.e. in blastic crisis (BC) or accelerated phase (AP), were inhibited by all-trans-retinoic acid (tRA) approximately 1000-fold more potently than those from chronic phase (CP) CML patients (median ic50 = 10−9 M tRA for six CML-AP/BC cases vs > 10−6 M tRA for seven CML-CP cases). A similar activity pattern was observed for the stereoisomer 13-cis-RA (cRA). There was no apparent correlation of CFU-GM retinoid sensitivity with cloning efficiency or other colony characteristics. Interferon alpha-2a (INFα) alone strongly inhibited CFU-GM growth in all four CML-AP/BC cases (ic50 ⩽ 250 IU/ml) and three out of seven CML-CP cases (ic50 ⩽ 500 IU/ml), but there was little or no interactive effect between various concentrations of tRA and INFα (50 IU/ml) on CFU-GM from either CML-AP/BC or CML-CP cases. These results suggest that CML-AP/BC CFU-GM have some intrinsic molecular alteration(s) which markedly enhances their responsiveness to tRA and cRA, which may be clinically exploitable.
Url:
DOI: 10.1016/0145-2126(94)90055-8
Affiliations:
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A similar activity pattern was observed for the stereoisomer 13-cis-RA (cRA). There was no apparent correlation of CFU-GM retinoid sensitivity with cloning efficiency or other colony characteristics. Interferon alpha-2a (INFα) alone strongly inhibited CFU-GM growth in all four CML-AP/BC cases (ic50 ⩽ 250 IU/ml) and three out of seven CML-CP cases (ic50 ⩽ 500 IU/ml), but there was little or no interactive effect between various concentrations of tRA and INFα (50 IU/ml) on CFU-GM from either CML-AP/BC or CML-CP cases. These results suggest that CML-AP/BC CFU-GM have some intrinsic molecular alteration(s) which markedly enhances their responsiveness to tRA and cRA, which may be clinically exploitable.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Sagayadan, Grace E" sort="Sagayadan, Grace E" uniqKey="Sagayadan G" first="Grace E." last="Sagayadan">Grace E. Sagayadan</name></region><name sortKey="Ahearn, Greg" sort="Ahearn, Greg" uniqKey="Ahearn G" first="Greg" last="Ahearn">Greg Ahearn</name><name sortKey="Dutcher, Janice P" sort="Dutcher, Janice P" uniqKey="Dutcher J" first="Janice P." last="Dutcher">Janice P. Dutcher</name><name sortKey="Gallagher, Robert E" sort="Gallagher, Robert E" uniqKey="Gallagher R" first="Robert E." last="Gallagher">Robert E. Gallagher</name><name sortKey="Hallam, Steven J" sort="Hallam, Steven J" uniqKey="Hallam S" first="Steven J." last="Hallam">Steven J. Hallam</name><name sortKey="Hu, Xiao Ping" sort="Hu, Xiao Ping" uniqKey="Hu X" first="Xiao-Ping" last="Hu">Xiao-Ping Hu</name><name sortKey="Sun, Nancy" sort="Sun, Nancy" uniqKey="Sun N" first="Nancy" last="Sun">Nancy Sun</name><name sortKey="Thompson, Deborah" sort="Thompson, Deborah" uniqKey="Thompson D" first="Deborah" last="Thompson">Deborah Thompson</name><name sortKey="Wiernik, Peter H" sort="Wiernik, Peter H" uniqKey="Wiernik P" first="Peter H." last="Wiernik">Peter H. Wiernik</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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